Certainly the first major national ad campaign to throw around phrases like "But sometimes polyps develop on the colon of mankind." 

Look for a new Robert Williams book from Fantagraphics in the fall of 2009.  

On Saturday, May 17th, Overkill Shop in Berlin presents "Cheech Wizard goes to Berlin" with artwork by Vaughn Bodé, featuring an appearance by Mark Bodé and celebrating the launch of a limited-edition Bodé sneaker from Puma. The sneakers look pretty sweet (especially riding a Peter Bagge-designed Manik skateboard, I bet), though for me personally they take 3rd place to the Gary Panter-designed Simpsons Vans and Jim Woodring's custom-designed Chucks.

This is undoubtedly one of the unlikeliest ad campaigns ever: David Boring, spokesman/model for Hong Kong fashion company Chocoolate.